Given the high percentage of women with low vaginal Lactobacillus spp. Common BV symptoms include vaginal discharge, increased vaginal pH, itching, fish-like odor, and burning when urinating 5. Bacterial vaginosis (BV) is a condition in which the vaginal microbiome has a deficiency of lactic acid-producing bacteria with increased numbers of anaerobic bacteria such as Gardnerella, Atopobium, Megasphera, Prevotella, and Sneathia 1, 2, 3. Some women have a vaginal microbiome that is dominated by non- Lactobacillus species, especially Black and Hispanic women 4. The vaginal microbiome is commonly dominated by one species of Lactobacillus (e.g., L. Here, we propose a great opportunity for large clinical trials with probiotic strains isolated from the vaginal tract (e.g., Lactobacillus crispatus) and administered directly into the vagina after pretreatment. Furthermore, we provide our understanding of why current clinical trials with probiotics have had mixed results, which is mainly due to not administering the correct bacteria to the correct body site. In this review, we discuss the advantages and challenges of current BV treatments and interventions. Live biopharmaceutical products/probiotics and vaginal microbiome transplantation (VMT) have also been tested in clinical trials for BV. The current recommended first-line treatment for BV is antibiotics, despite the high recurrence rate. BV is a common and recurring vaginal infection among women of reproductive age and is associated with adverse health outcomes and a decreased quality of life. Bacterial vaginosis (BV) is a condition in which the vaginal microbiome presents an overgrowth of obligate and facultative anaerobes, which disturbs the vaginal microbiome balance.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |